Enhancing Antitumor Immunity Perioperatively

Catechins and antitumor immunity

Numerous laboratory and clinical studies have reported that the green tea catechin extract Polyphenon E exert anticancer activity, but the underlying mechanism of action was elusive. We have recently shown that Polyphenon E exerts antineoplastic effects by antagonizing tumor-induced myeloid derived suppressor cells (MDSCs).

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

Cancers can escape immunesurveillance by diminishing the expression of MHC class-I molecules (MHC-I) and components of the antigen-processing machinery (APM). Developing new approaches to reverse these defects could boost the efforts to restore antitumor immunity. Recent studies have shown that the expression of MHC-I and antigen-processing molecules is transcriptionally regulated by NOD-like r...

Induction of Protective Antitumor Immunity

Polyamine blockade promotes antitumor immunity

The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulat...

Enhancing Calf Immunity through Nutrition

Dairy calves are extremely susceptible to gastro-intestinal disease during the preweaned period. The risk for disease decreases as the calf ages; therefore, I think it is important to break the pre-weaned period up into at least 2 distinct phases that likely need to be managed differently, early life (1 and maybe the 2 week of life) and the remaining time the calf is fed fluid (milk or milk rep...